HDWhen We First Met
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HDWhen We First Met
The attainment of LLDAS is an important treatment goal for people affected with SLE, as it has been associated with protection from flares and damage accrual [13]. In this study, we analysed the characteristics of HDAS episodes which were defined by the first attainment of LLDAS after patients experienced HDAS. Our study sheds light on the heterogeneity of the duration of these HDAS episodes. Longer duration of HDAS episodes and multiple recurrent HDAS episodes were strong predictors for damage accrual. Many factors can determine the duration of an HDAS episode, but one important consideration was the baseline disease activity. Higher SLEDAI-2K at the onset of HDAS was associated with longer HDAS episodes, which in turn was associated with an increased likelihood of damage accrual.
In late January, PIH/ZL began training the first 55 women and men as Pwojè Kore Fanmi HDAs. The HDAs will soon begin working in the countryside, providing services to families who have been targeted as needing assistance. In past models, community agents would provide similar services to all families. This new model tailors services, addressing each family's specific needs. The HDAs will return every month through September for further training and support.
Yes, NotSoTechnical. The FileVault bug is one that seems fairly known about. I saw a number of threads discussing it within the first few pages, and the only solutions seem to have been wait for Apple to come up with a fix or reinstall OS X.
In a clinical trial, Papadoupoulos and coleagues (2005) assessed the effectiveness of a novel regimen of tandem HDC (THDC) with autologous stem cell transplantation in the treatment of patients with poor risk lymphoma. A total of 41 patients (median age of 40 years, range of 15 to 68 years) with poor risk non-Hodgkin's lymphoma and HD were enrolled. Tandem HDC consisted of melphalan (180 mg/m2) and escalating dose mitoxantrone (30 to 50 mg/m2) (MMt) for the first conditioning regimen, and thiotepa (500 mg/m2), carboplatin (800 mg/m2), and escalating dose etoposide phosphate (400 to 850 mg/m2), (ETCb) as the second regimen. In all, 31 patients (76 %) completed both transplants, with a median time between transplants of 55 days (range of 26 to 120 days). The maximum tolerated dose was determined as 40 mg/m2 for mitoxantrone and 550 mg/m2 for etoposide phosphate. The overall toxic death rate was 12 %. Following HDC, 10 of 24 evaluable patients (42 %) were in complete remission. The 2-year OS and EFS is 67 % (95 % confidence interval (CI): 52 % to 81 %) and 45 %, (95 % CI: 29 % to 61 %) for the 41 patients enrolled; and 69 % (95 % CI: 525 % to 586 %) and 48 % (95 % CI: 30 % to 67 %) for the 31 patients completing both transplants. This THDC regimen is feasible but with notable toxicity in heavily pre-treated patients; its role in the current treatment of high-risk lymphoma remains to be determined.
Chopra and associates (1993) reported the results of 155 patients with relapsed or resistant HD who were treated with HDC followed by ABMR. At the time of transplant, 46 patients were primarily refractory to induction therapy, 7 were good partial responders, and 52 were in first relapse, 37 in second relapse, and 13 in third relapse. At 3 months 43 (28 %) patients were assessed as complete responders. Seventy-two (46 %) patients were assessed to have partial responses (PR). Twenty-four patients (16 %) showed no response or progression. At 6 months, 53 patients were assessed as complete responders. Thirteen patients in PR at 3 months had achieved a CR by 6 months, this occurring in 8 patients after radiotherapy to residual masses, and 5 patients without any further treatment indicative of slow resolution of their tumor masses. Fifty-one patients still had non-progressive disease with persistent CT abnormalities, 26 patients had relapsed with progressive disease, and 8 patients had died of progressive HD. Overall, 104 of 155 (67 %) had a good